The NanoTOES project is a Marie Curie Initial Training Network focused on research to assess the health and environmental impacts of nanotechnology products. This research studentship is in collaboration with the Centre for Ecology and Hydrology, Wallingford Oxfordshire, and aims to determine toxicity for a range of metal and metal oxide based synthetic nanoparticles. The research will focus in particular on toxic effects on the biochemistry (gene expression, protein biology, cell biology) and behavioral and population ecology of the model nematode Caenorhabditis elegans.
The 6 main objectives of this project are:
1. Identify mechanisms by which nanomaterials induce cellular stress and immune activation.
2. Correlate size, shape, composition, coating of nanomaterials with defined cellular responses.
3. Distinguish cell-specific from general cellular responses for cells from selected tissues.
4. Identify the relevance of bystander substances and contaminants for nanotoxicity.
5. Analyse the influence of biological compounds and entities on engineered NP.
6. Develop and modify laboratory methods to allow their application in the work-place and in the environment.
Programme FP7-NMP Project Reference: 264506